A few years ago I was in Vietnam and my travel partner got really sick, we went to a hospital and learned that he had contracted dengue fever from a mosquito bite. For over a week of our trip he was bedridden yet unable to sleep, it was miserable. Thankfully, he recovered and I got out unscathed, but there was a window of time that we were pretty concerned that he had contracted malaria (very similar symptoms to dengue) and that he would end up hospitalized (or worse) in a foreign country. The fear and suffering was very real, and so when I first started reading about gene drives to manipulate the malaria (and other disease) carrying gene out of mosquitoes I was quick assume that this could only be beneficial. If we could prevent the same pain, suffering, and even casualties caused by mosquito borne illnesses, then why wouldn’t we?
Gene drives involve genetically modifying the DNA of an organism, in this case the mosquito, to pass down certain desirable (to us) genes. Certain work involves genes which resist the parasites which cause malaria (Pugh, 2016), and a gene drive would mean that over time genetically altered mosquitoes reproduce and pass down this malaria resistant gene until the entire population had inherited it. Another example of how a gene drive might work in mosquitoes is that the genetic modification prevents the insect from having female offspring, slowly eradicating the species, and therefore its ability to spread disease. On the surface this seems like a no brainer, of course we should implement this. Alas, there are people who don’t quite see it that way.
One objection that may arise from the use of gene drives might be that we have duties to the ecological world which are ignored when we undertake the manipulation of a species in this way. Ecocentrists, such as Aldo Leopold, argue that as a whole we ought not to view ourselves as conquerors of this world, rather that we are part of the “land community.” This land community exists as something that we share holistically with all the other beings on it, including the plants, animals, soils, and waters. Included in this biotic community, inevitably, is the mosquito. Although an incredible pest (and potential carrier of deadly disease) the mosquito should not be considered an insignificant organism in any ecosystem, and therefore should not be eradicated by humans. While Leopold and other Ecocentrists would not reprimand anyone for killing any one given mosquito, using gene drives to phase them out of the community altogether is a blatant (albeit slow) disruption of an ecosystem, and furthermore asserts human dominance as the only driving force towards eradicating mosquitoes is for human benefit.
A counter-argument to Leopold’s dissent for gene-drives may uphold our duty to other people, our community. As Leopold argues that we should maintain and respect the integrity of a biotic community, he asserts this by comparing ecosystems to our own social communities, which we also have duties to. Unlike Leopold, I would not argue that our duties to the ecological world and our duties to our fellow humans are equal. I would argue that our duties to other people, for our sentient conspecifics, hold a higher value than our duties to mosquitoes. Although I do believe in respect for the environment and all of its component parts, I take more of a Kantian view on where are obligations lie in dire circumstances. In the case of gene drives we are comparing wiping out mosquitoes over several generations, and millions of cases of malaria in humans every year, resulting in not insignificant fatalities. Since we have a means to prevent profound human suffering, I think it is worth the ecological disturbance of slowly phasing out this species.
References
Leopold, A, The Land Ethic, A Sand Country Almanac, 1948
Pugh, J. Driven to Extinction? The ethics of eradicating mosquitoes with gene-drive technologies. J Med Ethics, 2016;42:578-581